Dornase alfa cleaves extracellular DNA to 5´-phosphodinucleotide and Deoxyribonuclease (human clone protein moiety); Dornasa alfa. Date of last search for all years available: 20 May Using the option ‘ Advanced search’, the following search terms were entered into the following fields. El impacto de primer año de tratamiento con dornasa alfa en los parámetros clínicos de pacientes con fibrosis quística: resultado de estudio brasileño.

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Discussion We described the clinical characteristics and outcomes of the patients included in the Brazilian Dornasz Fibrosis Quality of Life Trial Keep all appointments with your doctor and the laboratory. Dornase alfa is used to treat cystic fibrosis but does not cure it.

Dornase Alfa for Non-Cystic Fibrosis Pediatric Pulmonary Atelectasis.

Retrieved from ” https: In a placebo controlled trial investigating the effects of long-term treatment with dornase alfa, it was shown that in young patients with CF, dornase alfa maintains lung function and reduces alca tract exacerbations. This page was last edited on doornasa Februaryat A case-controlled study with dornase alfa to evaluate impact on disease progression over a 4-year period.

Dornase alfa proprietary name Pulmozyme from Genentech is a highly purified solution of recombinant human deoxyribonuclease I rhDNasean enzyme which selectively cleaves DNA. The routine concomitant treatments during the study follow-up are shown in Table 5. Part of these dornssa was pre viously published Pulmonary tests, airway microbiology, emergency room visits, hospitalizations, emergency and routine treatments were evaluated.

In addition, a clinical stability questionnaire was used to evaluate the clinical conditions in the previous month During the follow-up, 14 patients were lost for the following reasons: Optimal activity is dependent on the presence of divalent cations such as calcium and magnesium.


Patients were followed in five outpatient visits: There was a significant reduction in the number of emergency room visits due to acute exacerbations when T4 was compared to T0.

The importance of this publication resides on the fact that it was mostly prospective, following a standardized documentation used in all 16 CF centers, with a significant number dornassa patients. Sputum cultures were collected routinely and considered positive when the following microorganisms were presented in at least one sample: A significant improvement in Shwachman-Kulczychi score was observed in the older group.

Acute maxillary sinusitis caused by M.

In addition, salt loss syndromes, diabetes mellitusand genitourinary abnormalities are other clinical complications of CF 28. It has no effect on intracellular DNA. While no conclusive studies donrasa yet been published, dornase alfa is expected to be metabolized by proteases in biofluids. Please review our privacy policy. DrugBank does not sell nor buy drugs.


Recently, an association between the use of dornase alfa for a period of two years and the reduction in the rate of FEV alfz decline was observed in a large prospective observational study DNase recombinant human deoxyribonuclease.

Table 4 Chronic and intermittent colonization before and during the one-year treatment with dornase alfa in CF patients. The significant improvement in the Shwachman-Kulczychi score observed in the older drnasa can also be pointed as a positive outcome of the therapy, and when considered together with the favorable results in CFQ-R other domains 14it allows the conclusion that dornase alfa is an additional therapeutic option for CF.


Table 1 Outpatient clinic and emergency room visits, hospitalizations, and pulmonary function parameters in the last 6 months prior to the study entry, and at 6 and 12 months after dornase alfa initiation in patients aged years. Follow the manufacturer’s written instructions for the care of the nebulizer. Effect of aerosolized rhDNase Pulmozyme on pulmonary colonization in patients with cystic fibrosis. Routine treatments were based on respiratory physical therapy, regular exercises, pancreatic enzymes, vitamins, bronchodilators, corticosteroids, and antibiotics.

Identification of the cystic fibrosis gene: This article has been cited by other articles in PMC. Lower respiratory infection and inflammation in infants with newly diagnosed cystic fibrosis. In the last six months of therapy, chronic or intermittent colonization by P. When time points T0-T4 were compared, no significant differences were observed regarding the number of visits due to acute exacerbations.

What side effects can this medication cause? Dornase alfa for cystic fibrosis.

Dornase alfa – Wikipedia

Although information collected at T0 was based on retrospective data, it was important to obtain the standard patterns of care and clinical characteristics of this population before treatment.

Dornase alfa is used as an off-label treatment option for pulmonary atelectasis because limited treatment modalities exist after conventional therapy has failed. Any ampule that has been open for more than 24 hours should be discarded.

Enzymatic breakdown of this extracellular DNA appears to reduce sputum viscosity and viscoelasticity.