FRUCTOSE INDUCED HYPERURICEMIA PDF

Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans. Virgile Lecoultre, PHD1,; Léonie Egli, MSC1,; Fanny. Fructose-induced hyperuricemia and hyperuricaciduria is associated with a striking increase in the blood lactate concentration, a decrease in erythrocyte. As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial NO levels and.

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Fructose-induced hyperuricemia results in endothelial dysfunction and insulin resistance, and might be a novel causal mechanism of the metabolic syndrome. Studies in humans should be performed to address whether lowering uric acid levels will help to prevent this condition. Am J Physiol Renal Physiol ; This mechanism may substantially enhance the risk of hyperuricfmia in people who consume high amounts of sugar.

National Center for Biotechnology InformationU. After the infusion of fructose, 0. This article has been cited by other articles in PMC. In two patients with hereditary fructose intolerance HFI the peak blood uric acid levels were This study was supported by grant from the Swiss National Foundation for Science and by a grant from Ajinomoto Co.

The serum Pi levels decreased less in galactosemic patients after galactose administration than in patients with HFI after fructose infusion.

In two patients with HFI the uric acid excretion increased four- to fivefold after fructose administration; the increased uric acid excretion in HFI exceeded that of normal children. Please review our privacy policy. In addition, we observed that a serum uric acid level above 5. Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans.

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F—F [ PubMed ]. Author information Copyright and License information Disclaimer. No other potential conflicts of interest relevant to this article were reported. These effects are generally attributed to an increased UA production, as observed after intravenous fructose administration 2. Consistent with this hypothesis is the observation that changes in mean uric acid levels correlate with the increasing prevalence of metabolic syndrome in the US and developing countries. The increasing incidence of obesity and the metabolic syndrome over the past two decades has indcued with a marked increase in total fructose intake.

Closed symbols represent data fructpse after 4—6 days of HFrD.

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Parts of this study were presented in abstract form at Experimental BiologyBoston, Massachusetts, 20—24 April Furthermore, high-fructose intake over several days is associated with increased fasting UA concentration 1. Acknowledgments This study was supported by grant from the Swiss National Foundation for Science and by a grant from Ajinomoto Co. NO increases blood flow to skeletal muscle and enhances glucose uptake.

As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial NO levels and induces insulin resistance.

This effect appears to be specific for fructose. Blood glucose, lactic acid, and fructose levels were significantly increased after fructose, indhced serum magnesium levels did not change.

The serum Pi level decreased 2. Journal List Diabetes Care v.

Open in a separate window. The lack of hyperruricemia in galactosemia patients indcued galactose ingestion may be explained by the observation that galactose is phosphorylated more slowly than fructose.

Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans

Animals deficient in endothelial NO develop insulin resistance and other features of the metabolic syndrome. Nutr Metab Lond ; 9: The mean blood inorganic phosphate Pi levels were significantly less than the mean fasting value after fructose.

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Because the metabolic effects of fructose show significant sex differences, it remains to be assessed whether the same effects are observed in female subjects. In three patients with galactosemia, increases in blood uric acid levels after galactose ingestion were similar to those in normal children after fructose, but less than those in patients with HFI after fructose.

Published online Aug Support Center Support Center. The mean uric acid excretion, expressed as milligrams per mg urinary creatinine, was 0.

Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans

We recently reported that uric acid reduces levels of endothelial nitric oxide NOa key mediator of insulin action. Ingestion of a high-fructose meal increases blood uric acid UA concentration in healthy subjects 1.

It has not been assessed, however, whether UA also increases when fructose is administered as several small indued instead of one single large load or whether a high-fructose diet HFrD impairs renal UA clearance UAC or fractional excretion UAFE as observed in rats 3. Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects.

These studies support the hypothesis that fructose-induced hyperuricemia results from degradation of adenosine monophosphate.