GLICÓLISE E DESVIO DAS PENTOSES GLICOSE MITOCÔNDRIA. CICLO DE KREBS. BIOQUÍMICA BÁSICA. PROFESSORA: ALINE MOREIRA DE SOUZA. As EROs diminuem a atividade do ciclo de Krebs e aumentam a atividade da As principais vias metabólicas envolvidas nesse processo, glicólise, ciclo do. A concentração de isocitrato, bem como a de outros intermediários do ciclo de Krebs, é mantida às custas de acetil-CoA e oxaloacetato, produtos da oxidação.

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Regulation of glucose and fatty acid metabolism in skeletal muscle during contraction. Zoppi IV ; Sandro M. Hirabara V ; Kaio F. Leandro VI ; Fe R. Barbosa I ; Igor H. Sampaio II ; Iracema H. The glucose-fatty acid cycle explains the preference for fatty acid during moderate and long duration physical exercise. In contrast, there is a high glucose availability and oxidation rate in response to intense physical exercise.

ROS reduces the glicollse of the Krebs cycle, and increases the activity of mitochondrial uncoupling proteins. The opposite effects happen during moderate physical activity.

Glicólise-Gliconeogenese-Via das Pentoses-Glicogenólise-Glicogênese by on Prezi

Thus, some issues is highlighted in the present review: Why does skeletal muscle prefer lipids in the basal and during moderate physical activity? Why does glucose-fatty acid fail to carry out their effects during intense physical exercise? How skeletal muscles regulate the lipids and carbohydrate metabolism during the contraction-relaxation cycle? Mitochondrial metabolism; muscle contraction; glucose-fatty acid cycle. Em contraste, sob elevada disponibilidade de carboidratos, utilizam predominantemente glicose.

Os carboidratos constituem uma valiosa fonte de energia ao nosso organismo. Esse conceito foi proposto originalmente por Randle e cols. Quando comparados os recordes mundiais em provas masculinas de maratona 42,2 km em The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. An introduction to the roles of the glucose-fatty acid cycle in sustained exercise. Hargreaves M, Thompson M, ed.


Biochemistry of exercise IX, – Human Kinetics;p. Nutritional strategies to enhance fat oxidation during aerobic exercise. Burke L, Deakin V, eds.

Regulation of skeletal muscle fat oxidation during exercise in humans. Med Sci Sports Exer. Effect of increase fat availability on metabolism and exercise capacity. Effect of lipid infusion on metabolism and force of rat skeletal muscles during intense contractions. Fat oxidation during exercise: Hargreaves M, Thompson M, eds.

Biochemistry of exercise, vol. Human Kinetics,p.

Regulation of glucose and fatty acid metabolism in skeletal muscle during contraction

Formation of hydrogen peroxide and nitric oxide in rat skeletal muscle cells during contactions. Free Rad Biol Med. Gardner PR, Fridovich I. Inactivation-reactivation of aconitase in Escherichia coli.

Biochemistry for the medical sciences. Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. Regulation of metabolic genes in human skeletal muscle by short-term exercise and diet manipulation. Am J Physiol Endocrinol Metab. Muscular long-chain fatty acid content during graded exercise in humans. Role of d acids in the transition from anaerobic to aerobic metabolism in skeletal muscle during exercise.

Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Glycogen utilization in leg muscles of men during level and uphill running.

Lawrence L, Dyck DJ.

Sala BioQuímica

The glucose-fatty acid cycle in skeletal muscle at rest and during exercise. Biochemistry of exercise IX. Human Kinetics, Scotland; Disordered lipid metabolism and the pathogenesis of insulin resistance. Mechanism of free fatty acid-induced insulin resistance in humans. Metabolic responses during distance running. Rev Bras Med Esporte. Regulation of substrate use during the marathon. Submaximal and maximal working capacity of elite distance runners.


Ann N Y Acad Sci. Physiological regulation of marathon performance. Mitochondrial function during heavy exercise.

Med Sci Sports Exerc. Brooks GA, Mercier J. Balance of carbohydrate and lipid utilization during exercise: An alternative function for human uncoupling protein 3: Cicko Bras Endocrinol Metab.

Antioxidant supplementation enhances the exercise-induced increase in mitochondrial uncoupling protein 3 and endothelial nitric oxide synthase mRNA content in human skeletal muscle. The production of reactive oxygen and nitrogen species by skeletal muscle. Biochem Biophys Res Commun. Tretter L, Adam-Vizi V. Inhibition of Krebs cycle enzymes by hydrogen peroxide: Role of reactive oxygen species in contraction-mediated glucose transport in mouse skeletal muscle.

Uncoupling protein 3 as a mitochondrial fatty acid anion exporter. Intrinsic and extrinsic uncoupling of oxidative phosphorylation.

Hypertriglyceridemia increases mitochondrial resting respiration and susceptibility to permeability transition. Acute effect of fatty acids on metabolism and mitochondrial coupling in skeletal muscle. Energy metabolism in uncoupling protein 3 gene knockout mice. Time-dependent effects of fatty acids on skeletal muscle metabolism.

Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo. Uncoupling protein 3 protects aconitase against inactivation in isolated skeletal muscle mitochondria.

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